Childhood Naso-pharyngeal Carcinoma
What is the optimal radiation dose in Childhood Ca Nasopharynx and the role of neo adjuvant chemotherapy in this sub group.
Childhood Naso-pharyngeal Carcinoma
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Summary:
Optimal Radiatuion dose?
We follow Children's Oncology Group (COG) protocol ARAR0331 activated in 2006.This protocol includes two strata. Patients with early stage disease receive radiation therapy only, and patients with locoregionally advanced or metastatic disease receive Induction chemotherapy followed by chemoradiotherapy. The protocol uses 5th edition of AJCC staging (1997)
Stratum A: Patients with AJCC Stages I and IIa will be treated with radiation therapy only. Patients with Stage I
disease will receive a total dose of 61.2 Gy, and patients with Stage IIa will receive a total dose of 66.6
Gy.
Stratum B:Patients with AJCC Stages IIb-IV will receive three cycles of Induction chemotherapy with cisplatin and
5-fluorouracil, and three additional cycles of cisplatin alone during radiation therapy.
The dose of radiation therapy will be based on the tumor response to chemotherapy in stratum B. If CR or PR to chemotherapy:61.2 Gy in 34 fractions, and if SD to chemotherapy: 70.2 Gy in 39 fractions.
I will be happy to send you the protocol if you e-mail me (moc.oohay|namhto_dijam#moc.oohay|namhto_dijam)
I just happened to read about chilhood NPC and came across a few papers which i am posting here.
I would like to know from seniors if there is any new change in the line of treatment.
1.Nasopharyngeal carcinoma in children: ten years' experience at the Tata Memorial Hospital, Mumbai,International Journal of Radiation Oncology * Biology * Physics
Volume 58, Issue 1 , Pages 189-195, 1 January 2004
2.Pediatric and Young Adult Nasopharyngeal Carcinoma Patients Treated With Preradiation Cisplatin and Docetaxel Chemotherapy,International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 4 , Pages 1116-1120, 15 March 2001.
3.Nasopharyngeal carcinoma in children: Retrospective review of 50 patients,
International Journal of Radiation Oncology * Biology * Physics
Volume 35, Issue 3 , Pages 485-492, 1 June 1996.
4.Nasopharyngeal Carcinoma in Children: Comparison of Conventional and Intensity-Modulated Radiotherapy,International Journal of Radiation Oncology * Biology * Physics
Volume 72, Issue 3 , Pages 728-736, 1 November 2008
Thanks for the Information.
This is a good review of what you are looking for http://www.ncbi.nlm.nih.gov/pubmed/21330921
/forum/t-344453/childhood-naso-pharyngeal-carcinoma#post-