There has been a recent shortage of Mitomycin-C (MMC) and pharma companies have stopped manufacturing it since there is not much profit. We all know since Negro etal's paper MMC has become a standard for CT+RT in Anal Canal Cancers infact. I would like to know are we prepared to replace MMC with another equally effective chemotherapeutic agent ? Do we have any better drugs that can give similar if not better results ?
Ca Anal Canal
Summary:
Is Mitomycin required with RT ?