How long should a breast cancer patient receive Tamoxifen http://isocentre.wikidot.com/forum/t-256451/how-long-should-a-breast-cancer-patient-receive-tamoxifen Posts in the discussion thread "How long should a breast cancer patient receive Tamoxifen" - 62/F, pT1No (1.2 cms tumor), ER/PR positive. Fri, 04 Sep 2026 13:44:06 +0000 http://isocentre.wikidot.com/forum/t-256451#post-840731 Re: How long should a breast cancer patient receive Tamoxifen http://isocentre.wikidot.com/forum/t-256451/how-long-should-a-breast-cancer-patient-receive-tamoxifen#post-840731 Sun, 01 Aug 2010 14:18:01 +0000 Nikhilesh Patil 416151 Thanks
The patient choose to stop Tamoxifen couple of weeks ago and she said her bleeding has stopped. She has a early stage breast cancer and chances of she failing is extremely low. Her GYN is organizing another USG and biopsy in 6 months time.

]]> http://isocentre.wikidot.com/forum/t-256451#post-840663 Re: How long should a breast cancer patient receive Tamoxifen http://isocentre.wikidot.com/forum/t-256451/how-long-should-a-breast-cancer-patient-receive-tamoxifen#post-840663 Sun, 01 Aug 2010 10:27:02 +0000 Rohit Malde 418807 Again in this scenario, Its the Risk Vs Benefit Equation.

The Risk of recurrence in ipsilateral and contralateral breast of women who has taken Tamoxifen for 4 years Vs 5 years is small.
This lady had indeed a very small pT1c No Mo , favourable Breast cancer, so the benefits are miniscule. Cant quantify this risk currently, it will require quite a lot of digging up into trials.

On the other hand, you can very safely re-initiate Tamoxifen as in such pts benign causes of Vaginal bleeding are much more (10 times) common than sinister causes. Incidence of Vaginal bleeding with tamoxifen = 10%

Incidence of Endometrial cancer, in the Swedish Tamoxifen Trial where they used 40mg Tamoxifen Vs Placebo was 1.67%, while in the NSABP 14 trial, the incidence was 1.05% and usually from all the trials, these Tamoxifen induced endometrial cancers have a better prognosis as they are usually Stage 1 with an extremely rarely ever reported deaths from it.

Arimidex is ideal in this scenario, but you cant force a pt to pay.
All what you can discuss with this pt is Risks of re-initiating tamoxifen Vs Risks of Stopping Tamoxifen.
Usually clincal experience dictates that women dont like the thought of having heir breast cancer ever back even if its a small risk.
For some reason, they are happy to have a womb cancer, as they could have a hysterectomy for that.

]]> http://isocentre.wikidot.com/forum/t-256451#post-840593 How long should a breast cancer patient receive Tamoxifen http://isocentre.wikidot.com/forum/t-256451/how-long-should-a-breast-cancer-patient-receive-tamoxifen#post-840593 Sun, 01 Aug 2010 05:48:47 +0000 Nikhilesh Patil 416151 Hello need help with this case,
62/F,
pT1pNo (1.2 cms), Infiltrating duct carcinoma, Grade II, ER/PR strongly positive. No LVI/EIC for anyother bad prognostic features.
NO CHEMO. Adjuvant RT to breast, treatment completed in April 2006. Started on Tamoxifen.
Now has bleeding per vaginum. Tamoxifen stopped. Endometrial biopsy - NEGATIVE.
Should this patient receive any other medication or do nothing? Patient cannot afford Arimidex.

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