Minor salivary gland tx of BOT

Re: Minor salivary gland tx of BOT

Tue, 16 Feb 2010 14:23:09 +0000

Treatment still will be surgery followed by RT. Take second opinion from good surgoen. Patient is young so surgery should be considered first.

Re: Minor salivary gland tx of BOT

Mon, 15 Feb 2010 17:25:41 +0000

Hi Nilesh, Are you confident about the histology? Surgery in BOT is challenging, radiation alone is not that great either. If you have some one who can debulk then go for it and then give RT (60-66Gy @ 1.8 - 2 Gy per #) if not then Radical RT (66-70 Gy) alone.

Re: Minor salivary gland tx of BOT

Mon, 15 Feb 2010 15:54:47 +0000

Hi Nilesh
As you know, radiotherapy alone is not optimal management of any salivary gland malignancy. Cure is rarely or never achieved. However in certain histologies - eg. adenoid cystic carcinomas of unusual sites that are not easy to resect- long term control can be achieved with radical doses i.e. the tumor remains stable or diminisges in size and remains that way for many years. (See Mendenhall's report http://www.ncbi.nlm.nih.gov/pubmed/14762884)
I cannot find good published evidence on acinic cell ca.
Surgery may indeed be morbid here, but do consider a second surgical opinion if possible/ if you consider that appropriate. Often a debulking surgery may be useful too just to reduce the tumor bulk followed by radical RT.

Minor salivary gland tx of BOT

Mon, 15 Feb 2010 06:48:02 +0000

35/f
Good GC
Midline Base tongue 3*4 cm lesion . No cervical LN pathy on MRI
Seen by surgeon. Feels Surgery will be too morbid. Sent for radical RT
Histology Acinic cell ca of salivary gland origin
Minor salivary gland ca are said to be relatively radioresistant.
What are your views?