Clinical and Biological Evidence (new threads) http://isocentre.wikidot.com/forum/c-101777/clinical-and-biological-evidence Threads in the forum category "Clinical and Biological Evidence" - Issues related to current clinical and biological evidence (not case based). Sat, 18 Apr 2026 12:53:55 +0000 http://isocentre.wikidot.com/forum/t-300448 Number of isocentres for SRS http://isocentre.wikidot.com/forum/t-300448/number-of-isocentres-for-srs What is the minimum number of isocentres required for SRS Wed, 19 Jan 2011 10:55:08 +0000 radtuxabhishek 495857 In Gamma Knife multiple isocentres are placed (ahem!) to create dose heterogeneity.

Is it justified to keep a single isocentre for say spherical target? Or multiple isocentres for the same? Or any other recommendation?

]]> http://isocentre.wikidot.com/forum/t-299394 Should we aim for homogeneity in IMRT plans? http://isocentre.wikidot.com/forum/t-299394/should-we-aim-for-homogeneity-in-imrt-plans Mon, 17 Jan 2011 13:03:08 +0000 radtuxabhishek 495857 One simple question that has been bothering me. Why should we aim for homogeneity of dose within the tumor volume when inherently the tumor is inhomogeneous? Is it required for comparing the plans or an esoteric ideation? Can we do without it?

]]> http://isocentre.wikidot.com/forum/t-298852 'p' value significance http://isocentre.wikidot.com/forum/t-298852/p-value-significance Sat, 15 Jan 2011 04:14:57 +0000 Ayan Basu 417597 interesting editorial in JNCI : http://jnci.oxfordjournals.org/content/103/1/2.full

members' comments

]]> http://isocentre.wikidot.com/forum/t-297443 Charlson Comorbidity Index http://isocentre.wikidot.com/forum/t-297443/charlson-comorbidity-index The first perpage discussion Tue, 11 Jan 2011 21:07:28 +0000 Santam Chakraborty 416676 In a new effort to provide interactivity to content creation we have enabled the per page discussion module which effectively allows us to comment on a created page.
The first such page is available now at the Charlson Comorbidity Index Score Page

A short review of the Charlson Comorbidity Index has been created at here. Do check out the page and add your comments….

]]> http://isocentre.wikidot.com/forum/t-261696 Making a strong case for Hyperthermia http://isocentre.wikidot.com/forum/t-261696/making-a-strong-case-for-hyperthermia Mon, 30 Aug 2010 16:14:15 +0000 radtuxabhishek 495857 Many a times I wonder, why shouldn't we use Hyperthermia given it's theoretical advantages as well as proven effect in many phase II/III trials. Just because it is cumbersome? Or that we need more research in this? What is the opinion (divided or consensus) opinion of the forum?

]]> http://isocentre.wikidot.com/forum/t-260320 Risk of Secondary Cancers http://isocentre.wikidot.com/forum/t-260320/risk-of-secondary-cancers Mon, 23 Aug 2010 05:14:25 +0000 radtuxabhishek 495857 I am interested to know:
1) What is the risk of secondary cancers, if any by delivery of IMRT. I am concerned about the "low dose cloud" including the leakages from the treatment head. Is there any robust data and/or estimates for the same?

2) It has been seen that majority of secondary cancers for patients treated for Carcinoma Cervix have been in bladder. Does that mean that when we perform brachytherapy and inadvertently the dose is "high" to any specific point on bladder, it would add on to risk of secondary cancer? This is more important because chronic atrophic changes in bladder mucosa is associated with a higher risk of turning into cancer.

3) What is the importance of dose delivered during daily imaging for IGRT. How much "extra dose" over and above prescribed dose is delivered to patient? Is there any defined protocol to limit the dose? Does delivering higher MU to the patient give a better image quality (for MVCT machines).

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